Our Cochrane review services deliver systematic reviews conducted to the standard of the Cochrane Handbook: methods conformant with the MECIR criteria, dual independent screening and data extraction, risk-of-bias appraisal with RoB 2 and ROBINS-I, GRADE certainty ratings presented in Summary of Findings tables, and reporting to PRISMA 2020. We are an independent practice with no affiliation to Cochrane; we build reviews to its published standard, and we support author teams preparing their own submissions to a Cochrane group.
Cochrane-style review support, fully independent of Cochrane
We run systematic reviews to the methodological standard of the Cochrane Handbook, and support author teams whose review is destined for a Cochrane group, without any affiliation to Cochrane itself.
4.9 / 5 across 1,194+ delivered projects
- Cochrane and PRISMA 2020 methods
- PhD methodologists
- 100% human-written, no generative AI
- Reproducible R and Stata code
- Free quote within 24 hours
- Mutual NDA on request
Independent of Cochrane, and plainly so
Before anything else, the disclosure that shapes this whole service: we are not part of Cochrane. We have no affiliation with, endorsement from, or formal relationship to Cochrane, its review groups, or the Cochrane Library, and we do not author or publish official Cochrane reviews. Cochrane reviews are produced by registered author teams working with a Cochrane group under its editorial process, and no external company can sell you one. Anyone who implies otherwise is misleading you. The word style in this service’s name is deliberate: it describes a methodological standard we build to, never a relationship we hold.
What can legitimately be offered, and what this service is, is methodological work performed to the standard Cochrane has published. The Cochrane Handbook and the MECIR criteria are public documents that define, stage by stage, what the most rigorous form of intervention review looks like. We build reviews to that specification for clients publishing in ordinary peer-reviewed journals, and we carry the methodological workload for author teams whose review genuinely is headed to a Cochrane group, with the client remaining the author of record and dealing with their review group directly. Our plain-language explainer on what a Cochrane review actually is covers the distinction in more depth.
What Cochrane-standard methods actually require
The phrase gold standard gets attached to Cochrane reviews because the standards are concrete and enforced, not because of the brand. Building to that specification means committing to specific practices at every stage, and each one adds real work that lighter reviews skip.
MECIR-conformant conduct
The mandatory MECIR items serve as the working checklist from protocol to publication, and we report conformance item by item so nothing rests on assertion.
Dual independent screening and extraction
Two reviewers screen every record and extract every data point independently, with disagreements resolved by discussion or a third methodologist and the process documented.
Mandated risk-of-bias instruments
Randomised trials are appraised with RoB 2 and non-randomised studies of interventions with ROBINS-I, outcome by outcome, with written support for every judgement.
GRADE and Summary of Findings
Certainty is rated with GRADE for each important outcome and presented in Summary of Findings tables, the format guideline panels and Cochrane groups expect.
Underneath those four pillars sits the discipline that makes them credible: an audit trail. Every screening decision, every extracted value, every risk-of-bias judgement, and every certainty rating is recorded with its reasoning, so that when an editor, a peer reviewer, or a Cochrane group asks why a study was excluded or a rating downgraded, the answer is a document rather than a memory. That record is delivered to you in full at handover.
How a Cochrane-standard review is built
- 1
Protocol to MECIR
We draft a pre-specified protocol whose question, eligibility criteria, outcomes, and planned synthesis satisfy the mandatory MECIR items before any searching begins.
- 2
Comprehensive, documented searching
A sensitivity-first search across the required databases and trial registers, independently checked line by line and recorded so it can be reproduced exactly.
- 3
Dual screening, extraction, and appraisal
Two reviewers independently screen, extract, and assess risk of bias with RoB 2 and ROBINS-I, with agreement statistics and a full audit trail of decisions.
- 4
Synthesis, GRADE, and reporting
Meta-analysis where pooling is defensible, GRADE ratings with Summary of Findings tables, and a manuscript reported to PRISMA 2020 with the flow diagram and checklists complete.
The heavy stages are carried by the same specialist services that stand behind the rest of our practice: our literature search service designs and runs the search, our data extraction service builds the dual-extracted dataset, and our GRADE and Summary of Findings service produces the certainty ratings. Where your own team is doing part of the work, our independent second reviewer service supplies the duplicate screening and extraction the standards demand.
Supporting author teams headed for a Cochrane group
Some clients come to this service precisely because their review is destined for the Cochrane Library. Their title is registered with a review group, the editorial expectations are clear, and what they need is capacity: hundreds of hours of screening, extraction, appraisal, and analysis performed to the group’s standard. We carry that workload as methodological support. The arrangement is straightforward and honest: you remain the author of record, you communicate with your review group directly, every methodological decision is put to you for approval, and how any contribution is acknowledged is governed by your group’s authorship policies and your own judgement. We never contact a Cochrane group on your behalf or represent ourselves as part of your team.
The same machinery also serves reviews that will never touch the Cochrane Library but must withstand hostile peer review, such as reviews supporting guideline submissions, health technology assessments, or regulatory dossiers, where assessors increasingly measure submitted evidence against the Cochrane bar regardless of where it was published. And because Cochrane pioneered the living review model, teams that need their evidence kept current after publication can pair this service with our living systematic review service for scheduled updates after publication.
Cochrane-standard versus a typical journal review
The honest trade-off is effort. A Cochrane-standard review costs more time and money than a lighter review because every safeguard is real work. The table shows what the standard buys you, so you can decide whether your question and destination journal warrant it. If they do not, we will recommend the lighter design rather than sell you rigour you do not need.
| Stage | Typical journal review | Cochrane-standard review |
|---|---|---|
| Screening and extraction | Often single reviewer, sometimes with spot checks | Dual and independent throughout, with a documented disagreement process |
| Risk of bias | Variable tools, sometimes study-level only | RoB 2 and ROBINS-I applied per outcome with written justifications |
| Certainty of evidence | Frequently omitted | GRADE for every important outcome, presented in Summary of Findings tables |
| Conduct standard | Whatever the journal enforces | Mandatory MECIR items, with conformance reported item by item |
What you receive
Every engagement ends in a complete evidentiary package, reported to the PRISMA 2020 standard, with the appraisal built on the RoB 2 instrument for trials and the ROBINS-I instrument for non-randomised studies. Whether the destination is a Cochrane group or a mainstream journal, the package is assembled so a methodological editor can trace every claim in the manuscript back to a documented decision.
- A pre-specified protocol satisfying the mandatory MECIR conduct items
- A comprehensive, reproducible search record across databases and trial registers
- Dual independent screening and extraction files with the full decision audit trail
- Outcome-level RoB 2 and ROBINS-I assessments with written justifications
- GRADE certainty ratings and Summary of Findings tables for every important outcome
- A PRISMA 2020 manuscript with flow diagram, checklists, and an item-by-item MECIR conformance report
How a Cochrane-standard review is quoted
We quote a fixed fee per project, agreed before any work begins, rather than charging by the hour. The number reflects the genuine load of the standard: the breadth of the question, the expected search yield, the number of outcomes carried through appraisal and GRADE, and whether we are delivering the whole review or supporting your author team through defined stages. Send the question, the intended destination, and any protocol or registered title you already have, and a PhD methodologist will return a plan, a timeline, and a fixed quote with no obligation to proceed. Support for author teams is priced by stage, so you pay only for the workload you actually hand over.
Frequently asked questions
- What is a Cochrane review?
- A Cochrane review is a systematic review prepared by an author team under one of Cochrane's review groups and published in the Cochrane Database of Systematic Reviews. It follows the Cochrane Handbook and the MECIR conduct and reporting standards, which mandate practices such as a pre-specified protocol, a comprehensive search, dual independent screening and data extraction, structured risk-of-bias assessment, and GRADE ratings presented in Summary of Findings tables. Because those standards are enforced editorially, Cochrane reviews are widely treated as the reference point for systematic review quality.
- Are you affiliated with Cochrane?
- No. We are a fully independent research services practice with no affiliation, endorsement, or formal relationship of any kind with Cochrane, its review groups, or the Cochrane Library. We do not author, publish, or fast-track official Cochrane reviews, and nothing we deliver carries Cochrane's name. What we offer is methodological work performed to the standard the Cochrane Handbook and the MECIR criteria describe, for clients publishing in ordinary peer-reviewed journals and for author teams preparing their own submission to a Cochrane group, where the client always remains the author of record.
- How long does a Cochrane review take?
- Author teams commonly spend one to two years, and sometimes longer, taking a Cochrane review from registered title to publication, because the standards demand a protocol stage, comprehensive searching, dual independent screening and extraction, structured appraisal, GRADE assessment, and multiple rounds of editorial review. A review run to the same methodological standard outside the Cochrane editorial system typically moves faster, since journal timelines replace the Cochrane group's editorial stages, but the conduct itself cannot be rushed. We give a realistic timeline at scoping based on the size of the evidence base.
- Can anyone write a Cochrane review?
- In principle yes, and in practice it is demanding. Cochrane does not require formal credentials, but a title must be registered with and accepted by the relevant review group, the team must include the methodological and topic expertise the group expects, and authorship follows the International Committee of Medical Journal Editors criteria of substantial contribution. The hundreds of hours of screening, extraction, appraisal, and analysis are what defeat most teams. That workload is where independent support helps, provided the author team retains intellectual ownership and deals with its review group directly, as our clients do.
- What is the difference between a Cochrane review and a systematic review?
- Every Cochrane review is a systematic review, but not every systematic review meets Cochrane's bar. The differences are enforcement and consistency: Cochrane reviews must satisfy the MECIR standards, use a registered protocol, apply dual independent screening and extraction, assess bias with the mandated tools, and present GRADE-based Summary of Findings tables, all checked editorially before publication. Systematic reviews in general journals vary widely in how many of those practices they follow. A Cochrane-standard review applies the same discipline voluntarily, which is why journals and guideline panels receive it well.
- What are the MECIR standards?
- MECIR stands for Methodological Expectations of Cochrane Intervention Reviews. It is the set of conduct and reporting standards every new Cochrane intervention review must meet, covering the protocol, the search, study selection, data collection, risk-of-bias assessment, synthesis, and the presentation of findings. Each item is graded as mandatory or highly desirable, which makes MECIR unusually concrete: it states exactly what a rigorous review does at each stage rather than offering general principles. We use the mandatory items as the working checklist for every review built under this service, and we report conformance item by item.
Tell us your question and where the review is headed, and we will scope a Cochrane-standard plan and return a fixed quote.
Free quote within 24 hours. 100% human-written by PhD methodologists.
Methodology reviewed by
Lead Review Methodologist
Leads protocol design, screening, and reporting across the practice, with a focus on reviews that survive editorial scrutiny.
Why researchers bring in a PhD methodologist
80+
systematic reviews are published every day (Hoffmann et al., 2021)
67.3 weeks
average time to complete a review in-house (Borah et al., BMJ Open 2017)
~70%
of published reviews rate critically low on AMSTAR 2 quality appraisal
4.9 / 5
our client rating across 1,194+ delivered projects
